Cocaine analogues are used as radiopharmaceuticals in DATScan SPECT studies. During the past decade several cocaine analogues have shown to bind with high affinity to the dopamine transporter (DAT) located in the membrane of the presynaptic nigrostriatal nerve terminals. The DAT is responsible for the reuptake of dopamine from the synaptic cleft. DAT SPECT imaging, therefore, offers the unique opportunity to study in vivo via striatal uptake measures,  the structural and biochemical integrity of the presynaptic dopaminergic nerve terminals in order to diagnose neurodegenerative disorders, mainly Parkinson’s disease.

The iQ-BRAIN module does further comply with the Guidelines released by the European Association of Nuclear Medicine (EANM).

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